More Xenotransplantation Advances

Even if they don’t lead
immediately to treatments in human beings, the announcement of two recent
advances in genetic engineering of organs provides more evidence of the
sort of technologies likely to hit the mainstream of medical technology
before the end of the next decade.

In mid-February researchers
announced in Science News that they had successfully transplanted
bladders grown in the lab into six beagles. The scientists grew the bladder
cells around a plastic form to make it take the shape of the bladder and
then implanted the artificial bladders in the dogs. Within three months
the artificial bladders were completely active and some of the dogs have
had the bladders for almost a year with no problems.

Obviously getting the technology
to work in human beings is a whole other problem, but these experiments
are doing for this technology what the early animal experiments on organ
transplantations did – they suggest solutions and help scientists better
understand the problems they will encounter when seeking to grow human
organs in the lab.

In a related story, Canadian
researchers are hoping to take that step of translating animal experiments
into a treatment for human beings sometime this year. Researchers there
expect for the first time to use a genetically engineered pig liver to
keep a human being alive while waiting for a liver transplant from a human
being.

Pharmaceutical company Novartis,
which has been harshly criticized by animal rights activists for its efforts
in genetic engineering, is reportedly ready to spend up to $1 billion
to develop a viable pig liver. To avoid the risk of spreading disease
from pigs to human beings, the pigs will be raised under special conditions
to assure they are disease free. The pigs are isolated from other animals
and housed in a sterile environment. The pigs are fed by hand to avoid
microbes that might pass from pig to pig while suckling.

The impetus to move forward
with this technology is especially strong in Canada which has a rather
low rate of human organ donation – only 12.1 donors per million people
compared to the U.S. with 17.7 donors per million people.

As I noted two weeks ago,
the Campaign for Responsible Transplantation attacked Americans for Medical Progress for highlighting former Chicago Bear running back Walter Payton’s
recent announcement that he has a rare fatal liver disease. The CRT attack
on AMP, however, seemed like an act of desperation. They tried to throw
everything but the kitchen sink at AMP – xenotransplantation might not
work, it poses a risk of transmitting disease across species, it could
be avoided by increasing the donor pool, etc.

There are many responses to
these claims (CRT doesn’t seem to keep up with recent scientific advancements
in genetic engineering) but as far as I can tell the bottom line is this:
animal rights activism in the medical experimentation field has been successful
largely to the extent that it has engaged people’s sympathies against
hurting animals, especially unnecessarily. But that play on emotionalism
is a double-edged sword, since most people are openly “speciesist”
who, when it comes down to it, will find the suffering and pain of Walter
Payton far more compelling and worthy of alleviation than that of a pig
whose death could save Payton’s life.

What seems to anger CRT to
no end is that AMP gave them a taste of their own medicine with their
focus on Payton. I say more power to them.

Companies Steel Themselves Against Competition

For the past several months
U.S. steel companies, their unions and Democrats on Capitol Hill have
been whining that steel manufacturers from Brazil, Japan, Russia and other
countries are “dumping” steel in the United States. These critics
charge that companies from these nations are unfairly selling steel at
a price that is simply too low for American firms to compete. As a letter
from 13 U.S. governors to President Bill Clinton summed up the case, “Our
businesses cannot compete with unfairly priced, dumped and subsidized
products from desperate foreign markets. Each day of lost market share
equals real job losses and serious financial consequences for a vital
American industry.”

Although the Clinton administration
initially resisted calls to take action against the “dumping”
of steel, the Commerce Department ruled in late March that Belgium, Canada,
Italy, South Africa, South Korea and Taiwan all illegally dumped stainless
steel into the U.S. market. Stainless steel from those nations could face
tariffs as high as 60 percent if the U.S. International Trade Commission
decides the “dumping” hurt domestic steel makers. Although stainless
steel makes up only a small percentage of the steel market, this decision
makes it all the more likely that the Commerce Department will rule that
Japan, Russia and Brazil illegally dumped hot-rolled carbon steel into
U.S. markets.

As with most “anti-dumping”
appeals, however, the real problem is not with the foreign producers but
with the domestic steel industry; special protectionist measures now will
only reinforce and exacerbate those problems.

As a September 1998 article
in The Economist noted, long-running protectionist legislation
on behalf of the steel industry has encouraged firms to avoid taking measures
to reduce their costs or improve their operating procedures. Whereas in
other countries consolidation of firms has followed relatively flat steel
prices, The Economist notes “in the hour or so it takes to
get from Gary, Indiana, to Chicago you will pass nearly half a dozen full-scale
integrated steel plants, each with its own supplier networks, inventory,
production schedules, marketing and sales force.” ThatÂ’s an extremely
expensive method of business for a rather undifferentiated commodity such
as steel.

In fact it is so inefficient
that the traditional steel industry faces serous domestic challenges from
small-scale competitors once derisively referred to by the big steel companies
as “mini-mills.” Unlike the traditional steel companies, which
use ion ore and huge blast furnaces, the mini-mills use scrap metal and
electric-arc furnaces. Dismissed only a few years ago as insignificant
players, mini-mill companies such as Nucor now produce almost 40 percent
of U.S. steel and Nucor recently passed U.S. Steel as the number one domestic
producer of steel.

The more traditional steel
companies have tried to run their own mini-mills with little success.
An Alabama plant, Trico, financed by a group of traditional steel producers,
lost nearly $40 million last year. The large steel companies with their
bureaucratic, old style production methods have been unable to replicate
the set of management processes and coordination necessary to make mini-mills
succeed.

The large steel companies
are using the current surge in steel imports, caused in part by the huge
boom in the U.S. economy, to seek quotas to protect them from their own
inefficient production methods. House Republicans and Democrats joined
together in late March to approve the Steel Recovery Act which would limit
the amount of steel imported into the U.S. to the average of level of
steel imports from July 1995 to July 1997.

This bill would be a disaster.
According to the Precision Metalforming Association, limiting steel imports
to this average would have left American industry 4 million tons of steel
short of what it needed. The result would be a dramatic rise in the price
of steel in the U.S., which would result in increased cost to consumers
— a special tax on consumers to benefit the steel giants. In addition
without an opportunity to sell its steel in the world’s largest market,
foreign nations won’t have access to the dollars they need to help recover
from the ongoing Asian economic crisis. Setting up protectionist barriers
in America now would be like throwing gasoline on a raging fire.

The regimen of protectionist
barriers on foreign goods such as Japanese cars already harms American
consumers (almost $1,000 per car in the case of the automobile quota);
the last thing Congress should be doing in the midst of AmericaÂ’s economic
boom is imposing even more burdens on business and consumers.

Gattaca: The Documentary

In the dystopic film, Gattaca,
Ethan Hawke plays a man in a world where genetic testing and engineering
run amok. Children’s DNA is tested at birth and their genetic makeup used
by the government and businesses to determine what sort of job they will
hold and the person they will marry. Just a scary fantasy, right? Maybe,
but Michigan is taking a giant step towards making some parts of that
fictional future come true.

Beginning in 1965 Michigan required
blood samples to be taken from all newborns. The samples were handed over
to the state for genetic testing. Like many such laws, this one was passed
to “protect” children — the blood samples were screened for treatable
genetic disorders such as hypothyroidism. Although the state claims to
be looking out for children, parents aren’t informed of the procedure
— my wife and I learned about the law from newspaper reports about the
law not from the Michigan hospital which took our daughter’s DNA on behalf
of the state.

In 1983, the Michigan legislature
passed a law requiring the state to keep the blood samples on file, but
didn’t specify for how long. State officials claimed that for liability
purposes it needed to keep the blood samples until the children turned
21, at which time the samples would be destroyed. The first wave of children
targeted by the law will turn 21 in 2003. As that date gets closer, however,
the state is already concocting new justifications for keep the samples
indefinitely and is already putting the samples to use in ways that should
frighten anyone concerned with fundamental civil liberties.

A privacy commission set up
by Michigan’s Republican governor, John Engler, recently issued a proposal
that the state should maintain the DNA samples literally forever. The
privacy commission (which seems rather unconcerned with people’s privacy
concerns), notes that DNA samples have already been instrumental in solving
crimes. In several high profile cases, DNA samples of children involved
in kidnapping and murder cases have been used to identify the victims
and the criminals who preyed on them. Police use of the DNA samples in
such cases currently requires parental consent, but it doesnÂ’t any sort
of court order. The privacy commission believes that status quo should
be maintained.

At each step of the way, the
state has pushed the boundaries. When it started taking DNA samples and
testing them in the 1960s it could have made the program voluntary —
large numbers of Michigan citizens probably would have allowed the state
to pay for genetic tests of their children, though clearly some would
have opted out. Similarly, the state could make the retention of the records
voluntary. It could allow parents the choice of whether or not to maintain
their children’s DNA for forensic use and it could give the children of
such parents the choice of whether or not to have the DNA samples destroyed
when they reach 18.

But of course the state doesn’t
do this because the argument at each stage is that the mandate is for
the greater good — it’s the government looking out for the poor defenseless
children.

Over time, though, the state
will inevitably continue to push the envelope and expand police access
to the DNA samples to promote the common good. Michigan cities are already
on the cutting edge of questionable police use of DNA.

In 1994, for example, Ann
Arbor, Michigan, was plague by a serial killer. Police suspected the killer
was an African American and knew some of his general habits but had little
else to go on. So they forced 160 African American men to submit to “voluntary”
DNA testing to exclude themselves as suspects in the killings. The tests
were voluntary in the same way that getting arrested is voluntary — those
who refused to give DNA often received police visits at work or had police
stop them on buses or on the street.

Blair Shelton was one of the
men who gave his DNA sample only after police harassment at his workplace.
Like all 160 men, Shelton was excluded as a suspect. The police eventually
caught the serial killer, but without any help from the DNA dragnet.

The nightmare was only beginning
for Shelton, however. Even though another man was convicted of the murders
and the DNA sample excluded him from being connected to the crime, the
Michigan State Police insisted they had to keep his DNA sample on hold
indefinitely. First the prosecutor claimed they had to keep the blood
sample on file until the convicted killer exhausted his appeals. The prosecutor
actually expected people to believe that if DNA samples of someone who
had nothing to do with the crime were destroyed, the real killer’s conviction
could be overturned. When that argument didn’t fly, the police argued
that if their crime lab destroyed the samples they might lose their accreditation!

Shelton had to sue and his
case spent several years in the courts. Finally in 1997 the Michigan Supreme
Court ordered the state police to destroy all blood samples they had taken
from suspects for the purpose of DNA testing. State police Capt. Richard
Lowthian actually told the Detroit News, “It’s a monumental change in
the way we operate. When we eliminate someone as a suspect, were’ going
to immediately destroy the records. We have no choice.”

But given the choice, Lowthian
clearly would have liked to maintain the records. And it is a matter of
time before the police begin lobbying the legislature to overturn the
Supreme Court’s ruling. All it will take will be a single high profile
murder or rape and police suggestion that if they had just maintained
their DNA samples, they could have cracked the case quickly.

This is, after all, how things
have gone in Europe. In many European countries widespread DNA testing
has become an all purpose tool for police. In a 1997 case in France, for
example, a judge ordered every man in the village of Plein-Fougeres to
undergo “voluntary” DNA tests in hopes of finding the murderer of 13-year-old
Caroline Dickinson who was raped and strangled while on a school trip
in the area in 1996.

In Great Britain, authorities
were on the verge of ordering 7,500 truck drivers to undergo DNA testing
after the murder of a visiting French student. Before the authorities
could put their plan into action, however, the killer was apprehended.
In fact in the United Kingdom DNA is routinely taken from criminal suspects
and stored in a national database. Of course British officials reassure
the public that the innocent have nothing to fear.

Police officials in the United
States look at such provisions and begin salivating. Apparently in agreement
with Michigan authorities, New York City Police Commissioner made headlines
when he called for maintaining a database of DNA sample from everyone
arrested in New York.

So pardon me if I’m a bit skeptical
when Michigan tells me that they’re only interested in protecting my daughter
by keeping her DNA on file indefinitely.

Gas Prices Hit Another All-Time Low in the United States

Gasoline prices in the United States reached an all-time inflation-adjusted
low in February, dropping to less than $1 per gallon nationwide. The average
cost of gasoline for all grades and including taxes reached 99.8 cents per gallon
on February 18 according to the Lundberg Survey of 10,000 gas stations nationwide.

After 18 months of perpetually declining prices, however, gas prices might
soon begin to inch upwards. “The price cutting is faster and deeper than it’s
been so far this year, but it is probably fizzing out,” Trilby Lundberg
told the Associated Press. “Behind the average price fall are a few lonely
no-change (prices) or price hikes here and there, from which I infer that retailers
and their suppliers can’t take it anymore.”

Add increased demand in the spring along with pollution control measures that
will likely add to the cost of gas, and American consumers will likely see an
upward correction over the next few months.

So much for those who 3 years ago were predicting an imminent oil shortage
and massive price hikes.

Source:

Gas prices dip to less than $1. Associated Press, February 21, 1999.

Hillary Clinton Denounces Forced Family Planning at Hague Forum

“Today I hope we can agree first and foremost that government has no place
in the personal decisions a woman makes about whether to bring a child into the
world,” U.S. First Lady Hillary Rodham Clinton told the delegates at the
Hague Forum. The Hague Forum is a meeting of government and non-government representatives
discussing the progress the world has made on population issues since 1994s UN
Conference on Population in Cairo, Egypt.

When it comes to family size, “that is a decision that should be made
freely and responsibly without government coercion,” Clinton said.

The Hague Forum produced the usual round of commentary about overpopulation.
The Boston Globe, for example, followed Paul Ehrlich’s lead with its editorial,
“A population Bomb.” World population will continue to boom, despite
the ongoing decline in total fertility rates, unless the United States increases
its family planning assistance to developing nations.

On the other side were conservatives such as Jay Ambrose who noted “Lester
Brown of the World Watch Institute is still watching and still announcing how
close we all have come to endless midnight, though … statistics still
show human welfare improving virtually any direction you look.”

There might be some middle ground here, though. Clinton, the Globe and Ambrose
all agreed that increasing the status and health options of women is of fundamental
importance for the 21st century.

Sources:

Hillary Clinton urges an end to forced family planning. Mike Corder, Associated
Press, February 9, 1999.

Population summit. Jay Ambrose, Scripps Howard News Service, February 9, 1999.

A population time bomb. Boston Globe, February 8, 1999.

Usual Suspects Attack Americans for Medical Progress over Xenotransplantation

As animal rights activists
and extremist environmental groups gear up to seek an outright ban on
the transplantation of organs from non-human animals to humans, Americans for Medical Progress‘s Jacquie Calnan wrote an excellent, widely published
op-ed on the importance of pursuing research on xenotransplantation and
similar technologies. She and AMP were subsequently attacked in a release
by Physicians Committee for Responsible Medicine, People for the Ethical Treatment of Animals, Greenpeace and
others.

Calnan’s op-ed, “Payton’s
hope” (available at http://amprogress.org/news/payton.htm) highlighted the problems of former Chicago Bear running back Walter
Payton, who recently announced he has a rare liver disease and may die
within two years if he does not receive a transplant.

As Calnan noted in her op-ed,
although there are 12,000 people on the waiting list for livers, only
about 4,000 such transplants are performed each year. In 1997 more than
1,000 people died while waiting for a matching liver. Calnan’s editorial
did an excellent job of highlighting animal rights hypocrisy, which is
why I suspect it was so quickly attacked. She repeated PETA celebrity
spokesman Bill Maher‘s recent quote to US Magazine that: “To those
people who say, ‘My father is alive because of animal experimentation,’
I say ‘Yeah, well, good for you. This dog died so your father could live.’
Sorry, but I am just not behind that kind of trade off.” Someone
should send Maher a thank you note for so succinctly summing up the animal
rights philosophy.

Calnan mentioned the newly
developed device I mentioned a couple weeks ago that uses pig cells to
help keep some people alive while waiting transplants. The fact is this
technology is here today and it is already saving lives, so the animal
rights and extreme environmental activists have to fall back on two claims
to discredit the technology.

The first is that the risk
of passing diseases from non-humans to humans is too high. Animal rights
activists have released claim after claim trying to make this point, but
most of the more serious ones have later turned out to be baseless. On
the other hand, like any other thing human beings do, there is always
some risk associated with it – the risk of some new deadly disease crossing
from non-humans to humans will never be zero.

But if our society was that
risk-averse no pharmaceutical drugs or medical technology would ever be
approved since the risk of a calamity from any new technology is never
zero. If this sort of principle actually guided medical technology, certainly
technologies that we take for granted, such as vaccination, would never
have been allowed since the potential risks were only poorly known at best.

The second claim is that there
are more than enough organ donors to go around. At the end of her article,
Calnan ask for more people to become organ donors, which is a reasonable
position, but the critics of xenotransplantation seem to assume that those
organ donors are here today. A recent press release from the Boston-based
Campaign for Responsible Transplantation claimed, for example, that Xenotransplantation
advocates “use statistics and emotion to make their case … some 3,000
transplant patients die each year on in the U.S. … [but a ] US General
Accounting Office report … reveals a potential organ donor pool of 150,000
people. This is in stark contrast to previous estimates of 5,000 to 29,000
people annually … if these organs are secured, it would solve the national
organ shortage, and completely eliminate the need for animal organ transplants.”

As is the typical modus operandi with
these groups, however, this last claim is a distortion. The GAO report
was written to explore different methods of evaluating the performance
of Organ Procurement Organizations, who are assigned the task of procuring
organs and getting them into the organ sharing network. In order to do
that sort of evaluation, the GAO wanted a baseline of the upper bound of
eligible organ donors, which it estimated at 147,000 in 1994 using a technique
to estimate actual deaths and then adjust the figures to determine how
many of those deaths would have had harvestable organs.

The interesting thing is that
in the very next paragraph after giving this estimate, the GAO notes the
limits of counting potential organs this way, “we found that both
the death and adjusted-death measures [which are the source of the 147,000
figure] have drawbacks that limit their usefulness, however, including
lack of timely data and inability to identify those deaths suitable for
use in organ donation.”

First, this explicitly concedes
that the 147,000 figure was obtained using a method that the GAO admits
has an “inability to identify those deaths suitable for use in organ
donation,” which is the crux of the problem with human organ donation
itself. If it was too expensive and time consuming for the GAO to go back
four years and decide how many people were eligible organ donors,
imagine the difficulty in trying to harvest those organs on the spot.

It is one thing to look back
several years later and say there were say 40,000 automobile deaths and
of those 6,000 were potential organ donors. It is another thing to be
in place to actually obtain those organs (a severe problem in organ donation
is that even among those who have signed organ donor cards and are good candidates
to donate organs, often the organs are no longer usable by the time doctors
are aware of the potential donor or get permission from family members
to proceed. This is a situation that is unlikely to change significantly
in the near future).

In addition, the CRT release
failed to note that the number organ donors has increased over the last
few years – but the number of people eligible for organ donation has increased
even faster. I suppose if PETA had its way, this wouldn’t be a problem
since there would be no animal research and fewer people would be transplant
candidates since the medical knowledge to save their lives simply wouldn’t
exist, but barring this it seems clear that future advances in medical
science are going to continue to drive the demand for organ donation at
a much faster rate than the increase in donated organs.

If anything the GAO report
on the failures of Organ Procurement Organizations to obtain more organs
is evidence of just how difficult it is going to be to increase the level
of organ donation, and further emphasizes why xenotransplantation and
similar technologies will likely play a key role in the 21st century – provided animal rights activists aren’t given the chance to
halt this important advance.