Researchers use gene therapy to restore rat liver functions

    Researchers have used genetically
modified liver cells to grow in the laboratory and successfully transplanted
the lab-grown cells into rats.

    The cells, called hepatocytes,
are generally difficult to grow under laboratory conditions. Transplanting
of such cells has been done in humans before, but with limited success
because of the difficulty in isolating enough hepatocytes.

    The technique described in
the Science articles inserts a cancer gene that forces the liver cells
to reproduce quickly. Then when enough of the liver cells are created,
researchers treated the cells with an enzyme that gets rid of the cancer
gene and halts the growth of the cells.

    The researchers then injected
the liver cells into rats who had 90 percent of their liver surgically
removed. Sixty percent of the rats receiving the genetically modified
liver cells survived to live normal lives, while all animals in a control
group that didn’t receive the cells died within three days.

Reference:

Researchers
experiment with genetic liver therapies
. The Associated Press, February
18, 2000.

Activists Fail — Barely — To Pass Circus Ban In Seattle

    In a preview to a battle that
is likely to get far more intense through the rest of this decade, a ban
on circus animals on city property barely failed to pass the Seattle City
Council. The proposed ordinance failed on a 5-4 vote after heavy lobbying
by animal rights activists and circus officials.

    Although there are a few places
around the country that already have local bans on circuses, Seattle would
have been the first major city in the United States to pass such a ban.

    Those who support the ban argued
that keeping animals in circuses is inherently cruel. As Diane Venberg,
an organizer for the Progressive Animal Welfare Society put the animal
rights case, “Bottom line, there’s no way to provide a natural habitat
for animals in a circus.”

    Anti-circus activist Claudine
Erlandson put a melodramatic touch on after the vote saying, “All Seattle
is crying. That’s not rain outside it’s tears.” But Erlandson and the
others do not intend to give up.

    “We’re going to re-group and
perhaps put the measure on the general election ballot,” said activist
Simon Chaltowitz.

    Whether or not PAWS or any
of the other anti-circus activists have the financial wherewithal to do
so is debatable. Both sides of the issue spent thousands of dollars on
ads before the vote and at least one activist expressed skepticism about
whether it was realistic to push for a ballot initiative so soon.

    Especially considering that
Ringling Bros. and other circuses targeted by the activists seem prepared
to fight back.

    Without a ballot issue, though,
it’s hard to tell how much legs the circus ban movement will have in the
United States. Getting a few animal rights-oriented individuals on elected
to the City Council is one thing, especially given typically low voter
turnouts in local elections in the United States, while getting voters
to agree with the animal rights position on a ballot initiative is another
thing, as activists have found in recent years with failed iniativies
such as their effort to require warning tags on fur in Beverly Hills.

    Personally, I doubt there is
any great desire among the electorate to ban circus animals. As Ringling
Bros. spokeswoman Joan Glavin underscored, the reason Ringling Bros. is
successful is precisely because so many people want to see exotic animal
acts.

    “As long as they [circus patrons]
continue to come by the millions, we will have animals. And we will continue
to protect the rights of people to see them.”

References:

Animal advocates regroup after Seattle defeats circus animal ban. The
Associated Press, February 15, 2000.

Seattle City Council defeats exotic-animal ban; activists to regroup.
John Zebrowski, Seattle Times, Feb. 15, 2000.

PETA Protests George W. Bush

People for the Ethical Treatment
of Animals didn’t make any friends with Republican presidential candidate
George W. Bush during the South Carolina primary. PETA decided to protest
Bush after the presidential candidate had just finished a pancakes-and-bacon
breakfast.

A PETA activist dumped a truckload
of dried manure at the doorstep of the restaurant where Bush had just
eaten. The activist then abandoned the dump truck used to deposit the
manure (with a requisite sign saying “Meat Stinks”) so that it blocked
Bush’s campaign bus. According to an Associated Press report on the incident,
“Police moved in, grabbed the man, and as they dragged him away he yelled:
“Meat is murder! Pork is death!”

Bush, who was taping a television
interview at the time, joked, “I sure am glad I had my bacon for breakfast.”

Reference:

“PETA protests Bush breakfast stop.” Associated Press, February 19, 2000.

Are Pharmacy Technicians a Danger to Your Health?

 

Today’s Headlines from Libertarian Sites

Congress
Should End The Confusion Over Medicare Private Contracting

by Robert E. Moffit (Heritage Foundation)

Watch
Your Language
by Walter Block (Mises Institute)

No
More Great Presidents
by Robert Higgs (Mises Institute)

Burning
Man Grows Up: Can the nation’s premier underground event survive
its success?
by Brian Doherty (Reason)

Conventional
Wisdom: Rediscovering the social norms that stand between law
and libertinism
by Jonathan Rauch (Reason)

Reality
Principles: An Interview with John R. Searle Eminent philosopher
John R. Searle defends free speech, free inquiry, and the Enlightenment

from Reason

The
Broken Blue Line: How to start a riot
by Jesse Walker (Reason)

Pot
Stickers: Indiana tries to punish a marijuana grower twice

by Stephen F. Hayes (Reason)

Seattle
Surprise: The WTO protests caught free-traders off guard. They
shouldn’t have
by Virginia Postrel (Reason)

Orphans
of Trade How to help all of Cuba’s children
by Nick Gillespie
(Reason)

Wiring
Washington: How to make a killing in cable
by Thomas W.
Hazlett (Reason)

Gold
Bugs Class action lawyers discover Silicon Valley
by Walter
Olson (Reason)

Faith
of Our Fathers: The Unbelief of America’s Founding Fathers

by Jim Peron (Laissez-Faire City Times)

Religious
Freedom and Private Property Rights
by Tibor R. Machan (Laissez-Faire
City Times)

Politics
in America, Part 9: A Psychotic Social Psychology, Continued

by Robert L. Kocher (Laissez-Faire City Times)

The
Power of Openness: Why Citizens, Education, Government and Business
Should Care About the Coming Revolution in Open Source Code
Software
from Laissez-Faire City Times

Karl
Popper and Friedrich Hayek: an Interview with Jeremy Shearmur

by Alberto Mingardi (Laissez-Faire City Times)

Scourge
Against the UN Moynihan’s Rebellious Daughter
by Richard
S. Ehrlich (Laissez-Faire City Times)

Columnist
Reflects New Deal View of Twisted Constitutional Views
by
Roger Pilon (CATO Institute)


   

The Associated Press recently
reported on the horror of the month — pharmacy technicians.

Pharmacy technicians are the
folks who do most of he work in modern pharmacies. Although they usually
lack any sort of formal training, they typically do the data entry for
drugs, count the actual tablets and slap the label on the pill bottle.
The pharmacist then checks everything to make sure the drug type and amount
is correct before the prescription is handed to the consumer.

According to some consumers
and regulatory bodies, this is an unacceptable state of affairs — they
want additional training required for pharmacy technicians and stiff licensing
requirements. The Associated Press gives a typical horror story. A woman
noticed the drug her 5-year old was taking contained a special warning
about giving it to children. The pharmacy technician told her this was
no problem. Unfortunately that was very bad advice, and as a result the
child suffered severe side effects including ongoing learning disabilities.

The Associated Press cites
a 1998 study by the Virginia Board of Pharmacy that found pharmacists
catching an average of 6.5 mistakes by technicians each week. Unfortunately
there are serious problems with that study. Only half of the 1,590 drugstores
surveyed bothered to respond and asking pharmacists to estimate how many
errors they spot in a given week is a very poor way of measuring the problem.

The real problem with the criticism
of pharmacy technicians, however, is that while technicians do indeed
make mistakes, the limited evidence available indicates they don’t make
mistakes any more often than regular pharmacists do. Last year, for example,
U.S. Pharmacopeia’s Medication Errors Reporting Program reported receiving
314 reports of pharmacy errors, half of which were made by technicians.
But what of the half that weren’t made by technicians? Logically, they
were almost certainly made by pharmacists.

Having spent a couple years
working as a pharmacy technician at a small pharmacy and a big chain the
basic problem in filling prescription is accurately processing data, not
having any special pharmaceutical skills or knowledge.

The main source of error is
still doctors who tend to right out almost unreadable prescriptions. It
is amazing in this day of hand-held computers, fax machines and cell phones
that doctors introduce a large risk into drug prescriptions by scrawling
out their drug orders. To really lower the risk of getting the wrong drug,
always have a doctor’s office phone in a prescription.

The second source of error
was the dizzying array of different compounds, many with similar names,
not to mention the occasional drugs that look very much alike (there are,
after all, only so many names and shapes available for the pills we take).
Such errors, in my experience, were uncommon but they did happen. However,
if a pharmacist and technician are doing their jobs, these never get out
the door. Not once did I ever see the process break down so a person go
the wrong drug.

On the other hand, such errors
are inevitable regardless of what sort of system is in place. States could
require that only licensed pharmacists have anything to do with dispensing
drugs, and such errors are still going to occur. There’s no way to get
around that.

But the presence of pharmacy
technicians probably increases the reliability of the system, since with
the pharmacy technician system the technician and the pharmacist both
check the prescription before it goes out the door. That is far superior
to having a single individual pharmacist doing the entire process from
beginning to end. To the extent that there is a problem with this system
it is that pharmacists don’t adhere to it. The Virginia Board of Pharmacy
interviewed dozens of pharmacists, with half of them saying they never
checked the results of their technicians.

Licensing of technicians or
limiting what technicians can do — both popular solutions among the regulate-it-to-death
crowd — will simply raise the cost of running a pharmacy while doing
very little to reduce the risk of a serious tragedy (largely because that
risk is probably already as low as it can get given the current economic
and time pressures).

Reference:

Proliferation
of pharmacy technicians raises questions of quality
. The Associated
Press, February 14, 2000.

The Fallacy of DNA Databases

 

Today’s Headlines from Libertarian Sites

A
Nation of Weather Weenies?
by Patrick J. Michaels (CATO
Institute)

What’s
With the Yield Curve?
by Frank Shostak (Mises Institute)

   

DNA evidence has proven extremely
useful in solving crimes. Many people convicted of crimes before the advent
of DNA evidence have been exonerated and released. But while DNA is a
very useful tool, it has its limitations and unfortunately governments
in Europe are misusing DNA — and of course law enforcement officials
in the United States want to join them.

The potential tragedy that
misuse of DNA evidence can cause was illustrated recently when police
in Great Britain admitted they misidentified a suspect based on DNA. Although
the suspect’s DNA matched DNA found at the scene of the crime, the gentleman
had an airtight alibi and after additional tests were performed the man’s
DNA was found to be slightly different. According to “experts” quoted
in numerous stories, this was a random problem that has only a 1 in 37
million chance of happening. Unfortunately that claim is nonsense — because
of the way Great Britain utilizes DNA evidence, there is about a 1 in
52 chance of such mismatches happening routinely.

DNA evidence is compelling
when comparing DNA found at the scene of a crime with that of a suspect
identified through traditional police methods. If a woman is killed and
her husband is a primary suspect, a DNA test might be useful in attempting
to exclude him as a possible suspect. The odds of any two randomly selected
individuals having a false positive is extremely low.

The problem with DNA starts
when governments start amassing huge databases. In much of Europe, DNA
samples are collected and kept on file for anyone arrested (much like
fingerprints). In Great Britain, for example, almost 700,000 DNA samples
are now included in a law enforcement database. Many law enforcement officials
in the United States want to do the same thing — take DNA from everyone
arrested and dump it into a huge database.

Then, anytime DNA is found
at a crime scene it can simply be compared to the samples in the database
and the perpetrator discovered more quickly. Except, as the British recently
found out, the result is likely to be junk. While there may be a 1 in
37 million chance of any two people in Great Britain giving the same result
on its DNA test, when you compare a DNA strand found at a crime scene
to almost the DNA of 700,000 samples, the odds of a false positive rise
to 1 in 52. That means for every 52 matches generated by such a search,
it should be expected that at least 1 is a false positive.

What happens when law enforcement
starts entering literally the DNA of literally millions of people into
its databases? Given the large number of arrests for drug and other related
offenses in the United States it is not inconceivable that within 10 years
such a DNA database would contain material taken from 20 million suspects.
At that point, the odds fall to 1 in 2 that any given match is a false
positive.

But actually the odds of a
false positive are much higher for a couple reasons. First, not all U.S.
law enforcement agencies use the same methods of quantifying DNA. When
DNA samples are analyzed laboratories usually look at up to 10 different
markers to compare samples. Using 10 markers yields the 1 in 37 million
odds of any two samples being identical. But many state agencies currently
collecting DNA evidence use only 6 or 8 markers (the more markers, the
higher the cost of the test). So existing DNA evidence is even more prone
to false positives.

Second, the 1 in 37 million
figure assumes that there is an equal distribution of DNA characteristics
throughout the population. This may be true when comparing samples of
two random individuals, but certainly will not be true of any DNA database
created in the United States. Some DNA characteristics vary by race, obviously,
and since a much larger percentage of minorities would be included in
a U.S. DNA database than non-minorities (compared to their distribution
in the normal population), the result would be that the distribution of
DNA characteristics in the resulting database would be far from even.
The only way around this would be to include the DNA of every person in
the general population which, unfortunately, would be self-defeating since
it would raise the odds of a false positive rise dramatically; assuming
a U.S. population of 260 million, running a random DNA sample against
such a database would on average yield more than 7 false positives for
every genuine match.

Now in Great Britain this may
not be much of a problem. British authorities have already done away with
their version of the Fifth Amendment — judges and juries can now consider
a suspect’s unwillingness to testify as evidence of his or her guilt.
There is also talk by the ruling Labor Party of doing away with trial
by jury for a whole host of crimes such as burglary (jury trials are said
to be too expensive). But the United States was founded on the view that
protecting the rights of the individual against the state is of paramount
importance. The People insisted that the right against self-incrimation
and the right to a trial by jury were preserved in the Bill of Rights
specifically to avoid the potential shenanigans that now dominate British
jurisprudence.

The recent false accusation
caused by a British DNA database is one more reasons to be skeptical of
poorly thought out European imports to the American legal system.

Should Despicable People Be Lawyers?

 

Today’s Headlines from Libertarian Sites

Do
GOP Voters Have a Choice When It Comes to Taxes?
by Doug
Bandow (CATO Institute)

The
Ecological Capitalist: an Interview with Lou Licht
by Don
Lobo Tiggre (Laissez-Faire City Times)

The
Hockey Business
by Peter Topolewski (Laissez-Faire City
Times)

Atlas
Slugged: Why Many Intellectuals Hate Ayn Rand
by Jim Peron
(Laissez-Faire City Times)

The
Anti-Austrian Hypocrisy
by Tibor R. Machan (Laissez-Faire
City Times)

Sex
Is the Answer!
by Sunni Maravillosa (Laissez-Faire City
Times)

Point
and Cast
by Jeff A. Taylor (Reason)

Easy
Money: Bank customers rebel at the price of convenience

by Thomas W. Hazlett (Reason)

Japan’s
Attack on Microsoft
by Shigeki Kusunoki (Mises Institute)

The
President’s Budget Proposes A High-Tech Pork Barrel
by Adam
D. Thierer And Gregg Vanhelmond (Heritage Foundation)

“Pure
and Perfect” Competition? By What Standard?, Pt.5
by Richard
M. Salsman (Capitalism Magazine)

   

Matthew Hale is not the sort
of person most people would want to invite over for dinner. A White Supremacist
and leader of the World Church of the Creator, Hale’s views about race
are despicable. But should his views on race be enough for the Illinois
to bar Hale from practicing law in that state?

Hale graduated from law school
at Southern Illinois University in 1998 and has passed the bar exam, but
the state refuses to grant him a law license saying his racist views make
it impossible for him to meet the criteria necessary to be a lawyer. As
the Associated Press sums up Illinois’ case against Hale:

[The Illinois State] Committee [on Character and Fitness] members
said his views would prevent him from fulfilling a lawyer’s duty not to
discriminate against litigants, jurors, witnesses or others for reasons
of race, religion or national origin.

The obvious solution would
be to monitor Hale and punish him if he should actually discriminate based
on race, religion or national origin rather than judging him guilty of
such offenses based entirely on his views on race.

But do we really want lawyers
who do not discriminate or hold prejudicial views? There was a case a
couple years ago about a lawsuit against a female divorce attorney. The
attorney specialized in representing women in divorce cases and generally
turned down men who asked her to represent them. On man turned down this
way sued her for sexual discrimination.

In fact a wide variety of prominent
lawyers hold prejudicial views that, using this sort of standard, would
have to be disbarred. Is a defense lawyer who insists that cops regularly
commit perjury likely to be able to treat potential police clients fairly?
Can an atheist lawyer truly be fair minded about potentially religious
believing clients (and conversely can a Southern Baptist lawyer really
take into account the rights of atheist clients?)

Clearly what should count in
such matters is not beliefs but actions. If Hale is guilty of racial discrimination
then Illinois should be free to disbar him, but punishing him based entirely
on his beliefs sets a dangerous, intolerable precedent.

Reference:
White supremacist appeals law license refusal to U.S. Supreme Court

from the Associated Press