NewzCrawler 1.7

For the past few months, I’ve been using Bloglines as an RSS reader, but it just didn’t scale very well with the huge number of feeds and news entries I was accumulating. So I decided to switch back to a Windows-based RSS reader. I had two requirements, however, which (oddly) turned out to be pretty difficult to meet:

1. It had to be able to let me subdivide the RSS feeds into multiple groupings and then automatically update those groupings (some RSS readers for Windows will only update the group you are currently viewing, which makes absolutely no sense).

2. It had to be able to store all data on an external hard drive so I could go back and forth from work without having to run some silly synchronization program.

As far as I can tell, the only decent RSS client that will do this in Windows is NewzCrawler.

Opposition MP Criticizes UK Approach to Animal Rights Extremists

Conservative Party MP Jacqui Lait recently criticized the government’s response to animal rights extremists in Great Britain.

In Parliament on July 7, 2004, Lait said,

We are now seeing increased levels of animal rights activity. Most of us are familiar with the saga of Huntingdon Life Sciences, the way in which City shareholders were targeted and the damage that that has done to the company. I pay tribute to Brian Cass and his staff for managing to refinance themselves and continue their valuable work.

There have been many instances of animal rights extremism since then. In the most recent quarter, from April to June this year, there have been what are euphemistically called “home visits”—22 to employees and 32 to company directors. The director of the building company Montpellier, which is involved in the construction of the Oxford animal research laboratory, resigned from the business. There have been 24 instances of phone, fax or e-mail blockade, which are immensely threatening to employees and, more worryingly, to their families, including children. I have seen the effect on senior research scientists when their families have been targeted. It has led to divorce, mental breakdowns and distressed children who have been unable to benefit from their childhood.

There have been 46 instances of damage to property, 94 publicly advertised demonstrations and 164 demonstrations that were unadvertised. Almost 3,000 people have been involved in protests. My office overlooks Portcullis House, and I remember one evening when people demonstrated outside about Yamanouchi for about two hours, disrupting not only the business that I was trying to conduct, but that of many other Members and members of the public.

There have been 80 arrests at demonstrations and 43 occasions when vehicles have been damaged. In many cases, corrosive fluid has been used, and in 33 cases tyres were cut or pierced. When corrosive fluid is used, tyres have to be changed anyway in case there has been some damage, and it is estimated that the costs of those attacks in one quarter alone are £250,000. We know that Cambridge university has had to scrap plans for its primate research laboratory and that Oxford is facing real trouble with its research facility as senior staff receive home visits. Huntingdon Life Sciences and Hall farm, which breeds guinea pigs for the research industry, have also been targeted.

I recognise that a small number of people are involved in the terror tactics; the vast majority of people who take a strong stand against the use of animals behave legally. The Home Secretary reportedly supports the Humane Research Trust, which is a legal organisation. The problem is, however, that those extremists are causing immense damage to our scientific and research base, and the Government do not appear to have the resolve to address the issue effectively. In the US and Japan, which are our main competitors in many of the research, pharmaceutical and bioscience industries, the perception is that the UK does not treat the issue seriously enough and will not take substantive action.

A new group called Victims of Animal Rights Extremism was launched in the House of Commons in April to try to help resolve the problem. It is a coalition that includes Amicus, the Bioindustry Association, the Association of Medical Research Charities, the Research Defence Society and Huntingdon Life Sciences. A Bill has been drafted to deal with the situation faced by people involved in this area, but the Government have still not made their position clear. I want the Minister to clarify whether they want that Bill, and if not, what way forward they propose to deal with the issues. It is the right of people working in those industries to have that clarification.

Lord Sainsbury, in his recent evidence to the Select Committee on Science and Technology, of which I used to be a member, pledged to introduce legislation, but rejected a single Bill, saying that he preferred to amend other legislation. The implication was that that would be a quicker route to deal with the problem. Specific legislation already exists in the United States, and seven members of SHAC—stop Huntingdon animal cruelty, the group targeting HLS—USA were recently arrested and charged under that legislation. It is therefore clear that such legislation does work.

For a while, I thought that the Government’s preferred method, which is Lord Sainsbury’s option of piecemeal legislation, might come to pass. There was a rumour that the Government were planning to amend section 14 of the Criminal Justice and Public Order Act 1994 to deal with home visits by amending—this seems slightly ludicrous—the Domestic Violence, Crime and Victims Bill, which has recently been in Committee. That rumour appears not to be coming true, but I hope that the Minister will tell us whether there is any substance to it. If not, what proposals does she have to deal with the issue of home visits?

If the Home Office is planning to amend that Bill in a piecemeal fashion, will the Minister also outline which legislation will be amended and how it will be done? For instance, is the Home Office planning to amend the Protection from Harassment Act 1997 in order to protect companies? There is no currently no protection for companies, and neither is there any requirement for companies to protect employees, even though they have an overriding duty of care to take appropriate steps to protect their employees.

Is the Minister planning to deal with home visits not by amending section 14 of the Criminal Justice and Public Order Act 1994, but by clarifying the Human Rights Act 1998, so that article 8 of the European convention on human rights, which deals with the right to respect for private and family life, takes precedence over article 10, which provides for freedom of expression? Is she planning to change the law so that companies do not need to spend significant amounts to secure injunctions, in addition to extra security costs that run to millions of pounds and reduce the UK’s competitiveness as a location for biomedical research? It cannot be right that the onus is so heavily placed on the victims to protect themselves from the extremists.

Will the Government address the issue of consistency in relation to convictions in the courts and encourage the Crown Prosecution Service and the courts to consider not only the one incidence of terrorism that has led to a person being in court, but the overall pattern of intimidation or terrorism, when they sentence someone charged with such offences? Could restraining orders such as antisocial behaviour orders be used? [Lait is informed that they are being used.]

. . .

I am delighted to hear that ASBOs have been used. The Minister now has the perfect opportunity to advertise that fact and to ensure that more courts and the CPS are aware of it. We still have to see what force ASBOs will have in the long run. They are taking out some of the young toerags for a while, but I am not certain how long that will last.

Given the draconian powers and lengthy sentences that have been introduced to deal with the war against terror, I ask the Minister what makes animal terrorists different. Should they not also be charged under that legislation, making their sentences longer?

The Government’s argument may be that specific legislation takes too long to introduce. With a general election imminent, I am sure that the Minister will agree that any postponement would mean waiting at least two years, because it is doubtful whether legislation could be passed before what is generally understood to be a proposed general election next May. It would take two years whoever won. Will she explain what the Government plan to do in the interim? If they do not wish to amend the legislation that I have mentioned, which legislation are they planning to amend? What ideas did Lord Sainsbury have? Which ones will the Minister advance? Will the Home Office or the Department of Trade and Industry take them forward?

What co-operation is there across Government to ensure that different Departments act in a concerted way so that a coherent body of law is produced instead of one specific measure? Does she plan to amend the legislation and—this may be a bit of a nerdy point—will that be done by statutory instrument or by amending Bills? Perhaps the Domestic Violence, Crime and Victims Bill could be amended as it goes through the House. Will the Government amend proposed legislation?

Who is gripping the issue to ensure that it is covered across Government and what time scale is envisaged to get a reform in place? Will the issue be dealt with before we prorogue in the autumn or before we rise for any general election next year? The previous Home Secretary—now the Foreign Secretary—was clear about the issue:

“We will not tolerate a small number of criminals trying to threaten research organisations and companies.”

This is an opportunity for the current Home Secretary to send out an equally clear and authoritative statement that he will not tolerate such activity.

At the most basic level, that would help to protect the Government’s own investment and the development of new medicines and research funding for life sciences. If we look closely at the pharmaceutical research base in the UK, we find that it has shrunk during the last two decades. Jobs and companies have moved quietly away. The decision to move is a complex one, but one factor in the equation is undoubtedly the unpleasant environment created by animal extremists. The irony is
that the countries to which the companies move often have less animal-friendly protection laws than we have in the UK. We need a strong skills base to take advantage of our innovation abilities. That means that the issue of animal extremism needs to be gripped and clear remedies proposed.
This is the opportunity for the Minister to come forward with clear proposals about what the Government plan to do to ensure that people who work in science, who are our lifeblood in this country, no longer need suffer the terror of phone calls in the middle of the night, attacks on their cars, being attacked with baseball bats, as Brian Cass of HLS was, or being terrorised, as a pensioner in my constituency was. That man’s pension came from a company which, following a complicated series of takeovers, acquired shares in HLS. That elderly gentleman and his elderly wife received phone calls right through the night. Posters were stuck on their garden gates. Posters were put on the streetlights down their road, saying, “This murderer lives at . . . ” and featuring their photo.

In this day and age, it is not acceptable that people who carry out a service to this country in any way, shape or form should face horror and terror from a small number who take extremism to its extremes and terrify, hurt and maim people physically and mentally. The Minister has the opportunity to set the record straight about what the Government wish to do to ensure that those people are not affected.

Ah, if only there were Jacqui Laits in the Labor government.

New Drug Tackles Gleevec Resistance in Mice — May Help Leukemia Patience

An article published in the July 16 issue of Science reports on efforts to find a compound that can reduce or eliminate resistance to a treatment for chronic myeloid leukemia (CML).

According to the National Institutes of Health, CML is “a cancer of blood cells, characterized by replacement of the bone marrow with malignant, leukemic cells.” CML is a genetic disease in which chromosome translocation causes an enzyme to signal for the body to produce excessive levels of white blood cells.

CML, however, is one of the few cancers that has an effective treatment. A drug called Gleevec was created specifically to interfere with the enzyme, thus stopping the overproduction of white blood cells.

There’s just one problem — there are a number of known genetic mutations which cause Gleevec to fail to work. For individuals with those particular mutations, Gleevec will not work.

Which is where a group of researchers from Howard Hughes Medical Institute, UCLA’s Jonsson Comprehensive Cancer Center and Bristol-Myers Squibb enter with research on a compound called BMS-354825. BMS-354825 is a compound designed to have the same effect as Gleevec while sidestepping that compound’s vulnerability to a number of genetic mutations.

In the Science article, HHMI investigator Charles Sawyers reports that the results of mice studies demonstrate that BMS-354825 virtually stopped CML in mice who have genetic mutations similar to those that cause Gleevec resistance in human beings. The researchers also demonstrated that BMS-354825 inhibits the production of diseased bone marrow progenitor cells in cultured human bone marrow cells taken from patients who are resistant to Gleevec.

Clinical research of BMS-354825 is still years away, and any number of problems could prevent the drug from being as effective in human beings as it is in mice. Still it is important to note that Gleevec, which has extended the lives of so many of those afflicted with CML, was the product of animal research as well.

In 1990, researchers at a number of laboratories demonstrated with a mice model of the disease that it was caused by a defective protein, BCR-ABL. In 1996, researchers demonstrated that Gleevec inhibited the growth of cells that expressed BCR-ABL in mice and later that it eradicated CML tumors in nude mice. In addition, pre-clinical toxicology testing in animals indicated the drug was safe enough to proceed with clinical trials.

Source:

New drug shows promise against Gleevec resistance in mice. Press Release, Howard Hughes Medical Institute, July 15, 2004.

Georgia holds Lottery for September Alligator Hunt

In July, George held a lottery to award permits to the 300 hunters who will be allowed to hunt alligators in that state’s second alligator season.

Each hunter will pay a $50 permit and anyone accompanying a licensed hunter must also pay a $50 fee to the state of Georgia. The bag limit is 1 alligator per permit.

In the 1960s, Georgia’s alligator population neared extinction, but today there are an estimated 200,000 of the animals in the state. In its 2003 alligator season, 180 hunters killed 73 alligators.

According to the Georgia Department of Natural Resources, about 450 nuisance alligators are removed every year with trapping.

Source:

Alligator hunting season starts in Ga. Elliott Minor, Associated Press, July 7, 2004.

Alligator Hunting Season for 2004. Press Release, Georgia DNR.