Activists Angered by Researchers Plans to Test Stun Gun Safety on Pigs

With the ongoing controversy in the United States over the safety of stun guns manufactured by Taser International, a researcher at the University of Wisconsin-Madison plans to use an animal model with pigs to test whether or not illegal drugs may be playing a role in the high profile deaths of individuals who have been tasered.

According to the Associated Press, since 70 people have died in North American since 2001 after being shot by Tasers (though that’s a pretty useless statistic, since it does not give any indication of how frequently Tasers are used by police).

Taser International maintains its devices are safe for use on human beings. The media, including the Associated Press, make much of the fact that the Tasers pump out about 50,000 volts of electricity, but typically fail to note that this electricity is delivered with only 0.04 amps.

Fifty thousand volts is certainly going to be extremely painful, but its difficult to see how a mere 0.04 amps could cause the death of an otherwise healthy person. Generally, fatal electrocution is believed to require 0.1 to 0.2 amps in otherwise healthy people.

So one of the possibilities is that those being shocked and killed by Tasers share some other factor that it is increasing their vulnerability to low-amp shocks.

Enter University of Wisconsin-Madison researcher John Webster. Webster has received a two year $500,000 grant from the Justice Department to study whether or not cocaine might make people’s hearts susceptible go going into fibrillation even from the sort of low-amp shock present in a device like the Taser.

Webster plans to conduct experiments shocking 150-pound pigs with a device to simulate the effect of a Taser in a human being. Webster will use three groups of pigs, one that will be administered cocaine but not receive the shock; another that will not be administered cocaine but will receive the shock; and a third that will be administered both cocaine and the electrical shock.

Webster told the Associated Press,

If the hypothesis is correct that Tasers do not electrocute the heart, then why are people dying in custody after they have been shot by Tasers? The people on our team have hypotheses why that’s true and we intend to answer that question. Our goals is to save lives.

Of course activists, especially People for the Ethical Treatment of Animals, were out in force urging calls and letters to the University of Wisconsin-Madison to stop the experiments.

But in doing so, PETA once again revealed its scientific illiteracy. As Webster mentions above, his group’s working hypothesis is that Tasers alone are not capable of causing the human heart to stop. Webster states that hypothesis in his grant documents, which leads PETA to conclude,

But rather than designing a study that would utilize information available from humans who have been stunned with Tasers, they elected to revert to cruel and antiquated tests on animals. John Webster was the perfect person to satisfy their safety claims, as he is already convinced that Tasers do not cause fatal cardiac arrest.

In another press release, PETA quotes from Taser critic James Angelo Ruggieri, who claims that,

The information conveyed in many other of Dr. Webster’s slides is also problematic. For instance, in one slide, Dr. Webster asks the question:

“Is 50,000 volts from the Taser the problem?”

Dr. Webster then answers his own question:

“No … the current, time duration and charge are too small to cause electrocution of the heart.”

This unsupported conclusion serves to undermine his hypothesis and appears to be an attempt to predetermine the outcome of future experiments Dr. Webster proposes to undertake–demonstrating an unprofessional research bias and violating the basic precepts of equipoise.

Wow, give that man a Nobel Prize. Ruggieri and PETA have single-handedly reduced the work that scientists will have to carry out by denying that stating or testing a hypothesis is a necessary part of scientific research. Instead, scientists from now on will simply make bald assertions without any sort of evidence or investigation — a lot like PETA and Ruggieri already do.

Perhaps someday Ruggieri will bother to learn why real scientists like Webster perform experiments with control groups and varying levels of blindedness.

University of Wisconsin-Madison professor Eric Sandgren, who heads the university’s animal use committee, told the Associated Press,

I think this is an outstanding example of one of those questions that can only be answered using animals. Boy, there’s been a lot of deaths frmo this. If the altenrative is to go back to using bullets, let’s find out how to make this safe.

Sources:

Professor to test stun gun theories on pigs. Ryan Foley, Associated Press, March 28, 2005.

UW-Madison and John Webster—a Lethal Combination. Press Release, People for the Ethical Treatment of Animals, Undated.

He Wants to Do What? Press Release, People for the Ethical Treatment of Animals, Undated.

Study Suggests It May Be Possible to Transplant Animal Embryonic Stem Cells to Grow New Human Organs

In a study published in February in the Proceedings of the National Academy of Sciences, researchers at the Weizmann Institute of Science published the results of their experiments in implanting embyronic stem cells from pigs into mice.

The researchers wanted to establish at what point it was best to implant the embryonic stem cells, so it took stem cells from varying stages of development of the pig embryo, and implanted them in the liver, pancreas and lungs of immune-deficient mice.

The researchers discovered that transplanting embyronic stem cells at too early or too late a stage would not result in new cell growth, but that if transplanted during the correct window of opportunity, the pig stem cells did lead to cell growth in the mice. Dr. Bernard Herring, at the Diabetes Institute for Immunology and Transplantation at the University of Minnesota, told National Geographic News,

What he [lead researcher Yair Reisner] has shown is that there’s a window of opportunity . If you obtain this tissue at a very defined point in time, then you can see development into islets [portions of the pancreas that secrete hormones like insulin] without risks such as teratoma formation. That’s clearly something that makes us feel very strongly that this could be a real opportunity, one that can be translated into tangible benefits much faster than other technologies.

In a statement about the research, Reisner said,

Considering the ethical issues associated with human embryonic stem cells or with precursor tissue obtained from human abortions, we believe that the use of embryonic pig tissue could afford a more simple solution to the shortage of organs.

This finding helps explain, in part, why previous efforts to transplant pig embryonic stem cells failed, since previous research had harvested the cells at a much later gestational age than what Reisner’s study found was optimal.

Of course there are still a number of major hurdles to overcome before such technologies could be used in human beings even if researchers figure out how to make embryonic stem cells produce cells in human beings, including producing pigs free of viruses that could possibly infect human beings and avoiding an immune response to the transplant of such cells.

Sources:

Pig Stem Cells to Be Used to Grow Human Organs? Stefan Lovgren, National Geographic News, February 15, 2005.

New Organs Could Come from Pig Embryos – Study. Reuters, February 14, 2005.

Some Activists Unhappy with HSUS' Use of Dead Pigs in Bear Experiments

The Humane Society of the United States is making some animal rights activist unhappy with an otherwise animal rights-style project.

The HSUS has reached agreements with Six Flags Wild Safari in New Jersey to carry out an experiment in using contraception rather than hunting to control bear populations. The HSUS will do two separate tests, one in which it will inject female bears with PZP and another where it will administer a chemical castration compound, Neutrosol, to male bears.

It is the PZP experiment that had New Jersey Animal Rights Alliance activist Joe Miele complaining in a post to AR-NEWS that “HSUS [is] exploiting pigs to save bears.” When injected into bears, PZP causes an immune system reaction that has a byproduct of preventing sperm from fertilizing a female’s eggs. PZP is obtained by taking tissue from dead pigs.

Vegan birth control it ain’t. Presumably it was undertaken on one of the days of the week when HSUS doesn’t oppose animal research.

Source:

Bear contraception to be tested at Six Flags. Brian Murray, New Jersey Star-Ledger, October 8, 2004.

Uncaged Campaigns Upset Over Korean Xenotransplantation Plan

Earlier this month the Associated Press reported that South Korea was preparing to spend $73 million to kick start an effort to mass produce organs for transplant from pigs into human beings. The South Korean project will included 90 researchers and aims to produce pigs whose organs can be transplanted into human beings by 2010.

Dan Lyons of Uncaged Campaigns quickly put out a press release opposing the plan under the headline, “Korean pig organ transplant plans sparks international alarm.” From reading the press release, however, the “international alarm” appears to be limited to Lyons perhaps being outraged about it while on an intercontinental flight.

In the press release, Lyons is quoted as saying,

Pig-to-primate organ transplant experimentation has caused controversy across Europe and North America because of the appalling cruelty involved and the danger of creating a new viral epidemic. With South KoreaÂ’s terrible animal welfare reputation – symbolised by dog eating – and the recent lethal SARS outbreak in the Far East, this announcement will ring alarm bells around the world.

What is the point of Britain refusing to allow cross-species transplants if they take place in countries with no regulation? Viruses donÂ’t need passports.

Well, it should ring alarm bells in Great Britain — if it remains a hostile venue for animal research, groundbreaking work such as on xenotransplantation will simply shift to Asia, leaving the UK at risk of falling permanently behind in biosciences research.

As far as pig-to-primate organ transplant experimentation causing controversy, at least in North America the only group that seems to really find this controversial are animal rights activists. Of course, by that standard the diet of 98 percent of North Americans “has caused controversy.”

Lyons continues,

Xenotransplantation is more like bioalchemy than biotechnology. Drug companies have sacrificed tens of millions of pounds and tens of thousands of innocent animals, only to find that the whole idea is a cruel deception. With 180 million years of evolution separating pigs from humans, and advances in stem cell technology and other alternatives, we urge the South Koreans to consider whether this is really a good investment.

Lyons, of course, neglects to mention that those advances in stem cell technology are do in large measure thanks to exactly the sort of basic animal research that Uncaged Campaigns opposes. Whether or not xenotransplantation will ever be a viable alternative to human organ transplants remains to be seen, but it is certainly much more likely to happen than seeing Lyons and his compatriots actually maintain a consistent, truthful position about animal research.

Source:

Korea to mass-produce pig organs for human transplants. Associated Press, June 1, 2004.

Researcher Discovers Method that Could Improve Lives of Thousands of Premature Infants

Infants born prematurely sometimes develop something called necrotizing enterocolitis — essentially part of the intestine becomes diseased and has to be removed. This is the single most common surgical emergency faced by premature infants, and accounts for 15 percent of deaths in premature infants weighing less than 1500 grams.

Many of those children who do survive have to be fed intravenously. After part of the intestine is removed, the remaining intestinal tissue will grow and become more functional, but there’s a Catch-22 — in order for this to occur, the individual has to take food orally, but many of these patients cannot be fed orally.

University of Illinois Urbana-Champaign researcher Kelly Tappenden has a possible solution that was recently published in the Journal of Parenteral and Enteral Nutrition — adding butyrate, a short-chain fatty acid, to an intravenous nutrition solution might also cause the intestine to grow and become functional.

Tappenden demonstrated that the treatment works in newborn piglets, which are frequently used to model newborn human infants. Adding butyrate to the intravenous solution given to piglets who had parts of their intestine removed caused the intestinal tissue to grow and become functional.

Tappenden said in a statement announcing the publication of the research,

. . . not only was there more gut, the gut that was there was more functional. When we added butyrate, the villi in the intestine increased in size, and they were able to transport more nutrients.

. . .

[This approach should work in humans] But it will depend on the patient, how much intestine he has left, and where that intestine is. We may not be able to take some patients off intravenous nutrition completely, but if patients can eat and just have one supplemental IV feeding daily, it would reduce the number of complications a great deal and increase their quality of life so much.

Source:

Research gives hope to preemies and Crohn’s patients. Press Release, University of Illinois at Urbana-Champaign, June 2, 2004.

Louisiana's Hog-Dog Debate

Louisiana is one of the last states where cockfighting remains legal, but lately its another form of animal fighting — dogs vs. hogs — that has lawmakers looking to amend state law.

The state House in May overwhelmingly passed a ban on so called hog-dog competitions by a 77-24 margin with 4 abstentions. The proposed ban now goes not to the state Senate. The proposed bill reads, in part,

It shall be unlawful for any person to organize or conduct any commercial
or private event wherein there is a display of combat or fighting among one or more
domestic or feral canines and feral or domestic hogs and in which it is intended or
reasonably foreseeable that the canines or hogs would be injured maimed mutilated
or killed.

Apparently rural hunters use dogs to hunt down and kill feral pigs. They train such dogs by using domesticated hogs and hold competitions for such dogs. Opponents of the bill have tried to cast the dispute as one of urban dwellers failing to understand and denigrating rural culture.

Some of that criticism led to a gaping loophole to be added to the legislation that allows hog-dog competitions to be continued for training purposes,

The provisions of this Section shall not apply to any competitive event in
which canines which are trained for hunting or herding activities are released in an
open area or an enclosed area to locate and corner hogs and in which competitive
points are deducted if a hog is caught and held unless by such actions it is reasonably
foreseeable that the canines or hogs would be injured maimed mutilated or killed.

Proponents of the legislation say it is needed because local prosecutors simply won’t bring hog-dog competitions to court under existing animal cruelty statues, but are they really going to be excited to bring cases that will rest on whether or not a jury can be convinced that such a competition was or was not for training purposes? Color me skeptical.

The full text of the proposed bill can be read here.

Source:

Friends, foes spell out hog-dog positions. Chris Frink, The Advocate (Baton Rouge, Louisiana), May 12, 2004.