Infants born prematurely sometimes develop something called necrotizing enterocolitis — essentially part of the intestine becomes diseased and has to be removed. This is the single most common surgical emergency faced by premature infants, and accounts for 15 percent of deaths in premature infants weighing less than 1500 grams.
Many of those children who do survive have to be fed intravenously. After part of the intestine is removed, the remaining intestinal tissue will grow and become more functional, but there’s a Catch-22 — in order for this to occur, the individual has to take food orally, but many of these patients cannot be fed orally.
University of Illinois Urbana-Champaign researcher Kelly Tappenden has a possible solution that was recently published in the Journal of Parenteral and Enteral Nutrition — adding butyrate, a short-chain fatty acid, to an intravenous nutrition solution might also cause the intestine to grow and become functional.
Tappenden demonstrated that the treatment works in newborn piglets, which are frequently used to model newborn human infants. Adding butyrate to the intravenous solution given to piglets who had parts of their intestine removed caused the intestinal tissue to grow and become functional.
Tappenden said in a statement announcing the publication of the research,
. . . not only was there more gut, the gut that was there was more functional. When we added butyrate, the villi in the intestine increased in size, and they were able to transport more nutrients.
. . .
[This approach should work in humans] But it will depend on the patient, how much intestine he has left, and where that intestine is. We may not be able to take some patients off intravenous nutrition completely, but if patients can eat and just have one supplemental IV feeding daily, it would reduce the number of complications a great deal and increase their quality of life so much.
Source:
Research gives hope to preemies and Crohn’s patients. Press Release, University of Illinois at Urbana-Champaign, June 2, 2004.